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Research Frontiers in Immunotherapy Resistance Mechanisms in Pediatric Leukemia

Investigating cellular and molecular mechanisms underlying CAR-T cell therapy resistance in childhood acute lymphoblastic and myeloid leukemias.

Leukemic Blast Metabolic Rewiring Under Immunotherapeutic Pressure
Tumor Microenvironment Immune Exclusion in Pediatric ALL
CAR-T Cell Exhaustion Signatures in Relapsed Childhood Leukemia
Epigenetic Silencing of MHC Presentation in Pediatric AML
Clonal Evolution and Immune Escape in Minimal Residual Disease
Mesenchymal Stromal Cell-Mediated Immunotherapy Evasion
Suppressive Myeloid Compartment Expansion During Leukemic Relapse
Interferon Signaling Dysfunction in Treatment-Resistant Pediatric Leukemia
Extracellular Vesicles as Mediators of Immune Checkpoint Engagement
Therapeutic Antigen Loss and Phenotypic Plasticity Under Selection

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