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Molecular Medicine

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Molecular Medicine

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Research Frontiers in CRISPR Base Editing and Prime Editing

Development of advanced gene-editing techniques that enable precise nucleotide conversions without creating double-strand breaks in DNA.

Chromatin Architecture as a Barrier to Precise Genetic Rewiring
Off-Target Deamination Landscapes in Therapeutic Base Editors
Prime Editor Processivity and RNA Template Engineering
Epigenetic Stability of Base-Edited Loci Across Cell Divisions
Mitochondrial Prime Editing and Organellar Genetic Rescue
Multiplexed Base Editing in Polyploid and Aneuploid Genomes
RNA-Protein Complexes as Escape Routes from Base Editor Mutagenesis
Temporal Dynamics of DNA Repair During Engineered Nucleotide Substitution
Prime Editor Structural Variants and Genomic Instability Signatures
Base Editing Efficiency in Heterochromatic and Repetitive DNA Elements

All Molecular Medicine PhD categories