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Medicinal Chemistry

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Medicinal Chemistry

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Research Frontiers in Proteolysis Targeting Chimeras Technology

Development of bifunctional molecules that recruit E3 ligases to degrade disease-causing proteins through ubiquitin-proteasome pathways.

Selective Degradation of Intrinsically Disordered Proteins
Temporal Control of Protein Elimination in Disease States
PROTAC-Induced Neomorphic Effects and Off-Target Degradation
Membrane-Impermeant Protein Targets via Targeted Degradation
Bifunctional Chimeras Against Undruggable Protein-Protein Interfaces
Subcellular Compartmentalization and Spatially-Restricted Proteolysis
Heterobifunctional Ligands for Mutant Protein Selective Destruction
E3 Ligase Selectivity and Tissue-Specific Degradation Patterns
Photochemically Gated Proteolysis Targeting Chimeras
Chimeric Degraders Against Aggregation-Prone and Metastable Proteomes

All Medicinal Chemistry PhD categories