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Medical Biology

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Research Frontiers in CAR-T Cell Immunotherapy Engineering

Design and enhancement of chimeric antigen receptor T cells for improved cancer recognition and elimination with reduced toxicity.

Spatial Choreography of CAR-T Trafficking and Tumor Infiltration
Metabolic Rewiring at the CAR-T Exhaustion Threshold
Synthetic Signaling Circuits Beyond Dual-Antigen Recognition
Microenvironmental Immunosuppression and CAR-T Persistence
Off-Target Activation and Bystander Toxicity Mechanisms
CAR-T Memory Establishment and Long-Term Surveillance
Tumor Escape Dynamics in Heterogeneous Antigen Landscapes
Engineering CAR-T Trafficking Through Endothelial Barriers
Epigenetic Plasticity Driving CAR-T Functional Heterogeneity
Combinatorial Immunomodulation with CAR-T Checkpoint Uncaging

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