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Gene Fusion

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Gene Fusion

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Research Frontiers in Oncogenic Fusion Protein Structure Determination

Characterizing three-dimensional structures of cancer-causing fusion proteins using cryo-EM and X-ray crystallography to enable targeted drug design.

Structural Plasticity of Oncogenic Fusion Proteins
Domain Architecture Remodeling in Cancer-Driving Fusions
Cryptic Binding Interfaces Unveiled by Fusion Events
Conformational Heterogeneity in Hybrid Kinase Domains
Neo-Epitope Emergence Through Fusion Protein Quaternary Structure
Structural Vulnerabilities in Aberrant Protein-Protein Interfaces
Phase Separation and Condensate Formation by Fusion Oncoproteins
Structural Basis of Subcellular Mislocalization in Fusion Cancers
Allosteric Mechanisms at Ectopic Fusion Junction Sites
Cryo-EM Structural Signatures of Recurrent Fusion Archetypes

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