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Gene Fusion

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Gene Fusion

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Research Frontiers in Fusion-Induced Protein Domain Shuffling

Analyzing how fusion events combine functional protein domains to generate novel enzymatic or binding properties in cancer cells.

Cryptic Domain Architectures in Fusion Oncoproteins
Neofunctionality Through Aberrant Protein Domain Recombination
Domain Interface Tension and Fusion Protein Instability
Evolutionary Escapes: How Fusions Bypass Protein Checkpoints
Orphaned Domains and Hidden Regulatory Landscapes
Structural Chaos at Fusion Junctions: Folding Paradoxes
Transactivation Wiring Through Promiscuous Domain Coupling
Subcellular Mislocalisation Triggered by Domain Geometry Shifts
Allosteric Hijacking in Chimaeric Protein Signalling
Synthetic Lethality Pathways Emerging from Domain Displacement

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