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Drug Designing

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Drug Designing

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Research Frontiers in Bioisosteric Replacement in Drug Optimization

Strategic substitution of molecular groups with similar electronic and steric properties to improve pharmacological properties.

Polar Isosteres in Hydrophobic Binding Pockets
Ring-Chain Bioisosteric Transitions in Pharmacokinetics
Cyclic to Acyclic Scaffold Morphing for Selectivity
Heteroatom Replacement at the Ligand-Protein Interface
Stereoisomeric Equivalence in Three-Dimensional Drug Space
Bioisosteric Linker Engineering for Cellular Penetration
Electron Isosteres in Structure-Activity Landscape Mapping
Conformational Mimicry Through Strategic Atom Swapping
Metabolic Stability Gains via Isosteric Core Substitution
Bioisosteric Masking of Unfavorable Pharmacophoric Elements

All Drug Designing PhD categories