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Crispr

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Research Frontiers in Base Editing Without Double-Strand Breaks

Development of cytosine and adenine base editors that achieve precise single-nucleotide conversions while minimizing DNA damage responses.

Precision Cytosine Conversion in Non-Dividing Cells
Off-Target Deamination Landscapes in Base Editor Variants
Prime Editing Without Genomic Scarring
Epigenetic Rewriting Through Adenine Base Editors
RNA-Guided Nucleotide Substitution in Therapeutic Targets
Multiplexed Base Editing at Disease-Critical Loci
Cellular Tolerance Mechanisms to Base Editor Activity
Subcellular Compartmentalization of Deaminase-Catalyzed Mutations
Transient Base Editor Scaffolds for Reversible Editing
Codon Optimization Through Split-intein Base Editor Systems

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