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NTHRYSPhD AssistanceBiophysics Medical Physics

Biophysics Medical Physics

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Biophysics Medical Physics

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Research Frontiers in Cryo-Electron Microscopy Structure Determination

Development and application of cryo-EM techniques to determine three-dimensional structures of protein complexes and macromolecular assemblies at near-atomic resolution.

Conformational Ensembles Beyond Static Atomic Resolution
Transient Protein-Ligand Interactions in Native Cellular Context
Phase Transitions in Biomolecular Assembly and Disassembly
Cryo-EM of Intrinsically Disordered Protein Complexes
Quantum Mechanical Effects in Cryo-Preserved Electron Density
Real-Time Enzymatic Catalysis Captured at Cryogenic Temperatures
Membrane Protein Dynamics Within Lipid Nanodisc Environments
Structural Heterogeneity in Pathological Protein Aggregates
Sub-Angstrom Precision in Metalloprotein Active Site Geometry
Temporal Resolution of Millisecond-Scale Biomolecular Transitions

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