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Biological Chemical Defence

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Biological Chemical Defence

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Research Frontiers in Botulinum Toxin Structure and Function

Structural biology and neuromuscular mechanism studies of botulinum neurotoxins at atomic resolution.

Zinc-Dependent Catalysis in SNARE Protease Mechanisms
Domain Translocation Across Neuronal Membrane Barriers
Structural Plasticity of the Toxin-Receptor Interface
Catalytic Proofreading in Synaptosomal Substrate Recognition
Botulinum Neurotoxin Structural Variants and Serotype Specificity
Metalloprotease Conformational Changes During Endosomal Acidification
Light-Chain Docking Geometry and Cleavage Selectivity
Structural Determinants of Toxin Persistence in Synapses
Disulfide Bond Architecture in Toxin-SNARE Substrate Coupling
Three-Dimensional Epitope Landscape for Immune Recognition

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